Kungani usebenzisa ama-SARM?
Ama-modulators we-androgen receptor akhethiwe (Ama-SARM) athengiswa njengemikhiqizo elingisa imiphumela ye-testosterone efana ne-anabolic androgenic steroids (AAS) kepha ngaphandle kwemiphumela emibi kakhulu ye-steroids. Empeleni, ama-modulators we-androgen receptor akhethiwe angamakhemikhali angakhuthaza noma avimbele ama-receptors omzimba abucayi anekhono lokwenza ngcono imiphumela emihle futhi anciphise nemiphumela engemihle ngokuya ngesenzo senhlanganisela.
Ama-modulators we-androgen receptor akhethiwe aziwa kakhulu emhlabeni wezemidlalo yezemidlalo namandla okwakha umzimba njengamakhemikhali angakhuphula isisindo samathambo, imisipha, nokulahleka kwamafutha ngaphandle kokuvala I-Hypothalamic-pituitary-gonadal axis (I-axis ye-HPG) noma i-estrogen ekhulayo.
Eminyakeni embalwa edlule, abacwaningi emhlabeni jikelele balethe phambili ukutholakala okuningi kumongo wokwenza ngcono ukutholakala komlomo nokunciphisa ubuthi obushubile balezi zidakamizwa ezithuthukisa ukusebenza. Kuyafaneleka ukukhumbula ukuthi ama-modulators we-androgen receptor akhethiwe asebenza kuma-receptor athile we-androgen emzimbeni atholakala ezicubu eziningi ezibucayi. Ama-Androgen receptors atholakala ku-vesicle yesidoda, i-prostate, izindlala zomjuluko, izitho zangasese, i-testis, i-ovary, amaseli we-gastrointestinal vesicular, amaseli we-thyroid, ubuchopho, isibindi,i-adrenal cortex, izindlala ezibusayo, nezinwele zezinwele.
Ama-modulators we-androgen receptor akhethiwe awenzelwe kuphela abasubathi bamandla nabakhi bomzimba be-amateur & professional. Lezi zinhlanganisela ziyasiza futhi kubantu abalwa nezinkinga zezempilo njengokuphazamiseka kwemisipha, ukulimala kwezemidlalo, ubuthakathaka, i-muscle atrophy ngenxa yokuguga, nokulimala. Yize kunemithi eminingi ekhona engakhuphula izinga lempilo futhi inikeze ukukhululeka enkingeni yezempilo, amaSARM anezinzuzo ezingeziwe zokunganuki nokungabi yi-methylated ngumzimba. Ngakho-ke, ama-modulators we-androgen receptor akhethiwe awaguquki amanye ama-estrogen asebenzayo noma ama-androgen compounds.
Futhi ayinabo ubuthi esibindini futhi le mfanelo ibenza inketho ekahle kubantu abaphethwe yizifo zesibindi ezikhona noma ababhekene nengozi eyengeziwe yobuthi besibindi. Ngamafuphi, ama-modulators we-androgen receptor akhethiwe azuzisa bobabili abantu abaphilile kanye nabantu abagula kakhulu abafuna ukukhulisa ikhwalithi yempilo yabo.
Enye yezinzuzo ezinkulu zabakhethi be-androgen receptor modulators yikhono labo eliyingqayizivele lokuvimbela noma lokunciphisa i-muscle atrophy lapho imisipha ingasebenzi emzimbeni. Ngokusobala, lezi yizindaba ezinhle kubasubathi nakubakhi bomzimba abasebenza ngokungakhathali egumbini lesisindo, nasensimini ukwenza ngcono nokugcina amandla, ubukhulu bemisipha, ukukhuthazela, ukuqina, namandla njengabakhethayo be-androgen receptor modulators kuthinta kahle inqubo ehlukile ukululama.
Ama-modulators amaningi we-androgen receptor anamandla okukhuthaza i-adenosine monophosphate-activated protein kinase (AMPK) eyindlela ehambisana ne-lipolysis ne-fat oxidation. Amakhemikhali asuselwa ku-testosterone afana ne-testosterone enanthate nawo anciphisa amafutha futhi andise imisipha kodwa ama-SAR, ngokungafani ne-anabolic steroids, awacindezeli kakhulu I-hormone evuselela i-follicle (FSH) futhi I-hormone yeLuteinizing (LH) ngaphandle kokuthi kuphathwe imithamo ephezulu kakhulu yalezi zinhlanganisela. Lokhu kuphakamisa ngokusobala ukuthi ama-modulators we-androgen receptor akhethiwe aphephile esikhathini esifushane kanye nesikhathi eside kunamakhemikhali asuselwa ku-testosterone.
I-Androgens inekhono lokuthi kungenzeka ikhulise ukwakheka kwethambo le-periosteal ku ithambo le-cortical kuyilapho izinhlanganisela ze-estrogen zicindezela noma zinciphisa lokhu kwakheka. Ngokwemigomo ye-layman, ama-androgens asiza ekwakheni ungqimba lwangaphandle oluhlangene, oluminyene lwethambo olusiza ukusebenza komzimba, ukuvikela izitho, nokugcina i-calcium. Ama-modulators e-androgen receptor akhethiwe nawo anekhono lokunciphisa ukuguqulwa kwamathambo e-trabecular kanye ne-endocortical. Kuyafaneleka ukukhumbula lapha ukuthi izinga eliphezulu lokuguqulwa kwamathambo ngokuvamile lihlotshaniswa nokulahlekelwa kwethambo elithambile, eliyisipontshi, elithambile, elithambile, nelibuthakathaka elitholakala eduze kwamalunga, ekugcineni kwamathambo amade, nangaphakathi umgogodla.
Ukwehlisa ukuphuma kwamathambo nokwandisa ukwakheka kwamathambo kusikisela ukuthi ama-Selective androgen receptor modulators ayizinketho ezinhle kakhulu kulabo abatholwa ukuthi bane-or osteoporosis. Ngamanye amagama, ama-Selective androgen receptor modulators ayizinhlanganisela ezimangalisayo zabantu abafuna ukunciphisa ukuqhekeka nokuqinisa amathambo.
AmaSARM Nokwakha umzimba
Ama-modulators we-androgen receptor asetshenziswayo asetshenziswa ngabakhi bomzimba nama-powerlifters ukukhulisa ukulahleka kwamafutha, ukukhulisa ubukhulu bemisipha, nokwenza ngcono amandla omzimba. Zisetshenziselwa ukuvuselela ukulimala, ukuthuthukisa amandla emisipha namathambo, kanye nokwenza ngcono inhlalakahle. Abanye abakhi bomzimba basebenzisa ama-SARM phakathi kwemijikelezo ye-anabolic steroid, imijikelezo ye-prohormone, nomjikelezo we-testosterone ukwelashwa kokuhamba kwesikhathi noma njengezinye izindlela eziphephe ngaphezu kwalezi zinhlanganisela.
Esikhathini esedlule, kwakusetshenziswa ama-anabolic androgenic steroids nama-prohormones ukubusa umhlaba wokwakha umzimba. Kepha la makhompiyutha anokhahlo kakhulu emzimbeni futhi asetshenziselwa ukudala imiphumela emibi emibi ebanzi efana nomfutho wegazi ophakeme, ukukhula komdlavuza wendlala yabesilisa, induna, impandla, i-gynecomastia, kanye nokwehla okuphawulekayo ekukhiqizeni i-testosterone yemvelo. Lezi ngezinye zezizathu zokuthi kungani abakhi bomzimba nama-powerlifters beqhubekela kuma-SARM - izindlela eziphephe kakhulu kuma-anabolic steroids nama-prohormones.
Ama-SARM adumile
Manje njengoba sesifundile mayelana nama-modulators we-Selective androgen receptor, ake sigxilise ukugxila kuma-SARM adumile, izivumelwano zawo, kanye nemiphumela ukuthola ukuqonda okucacile nokuphelele ukuthi ama-SARM asebenza kanjani, umehluko phakathi kwama-SARM, kanye ama-SARM ahlangana kahle ndawonye.
Thenga ama-SARM wangempela kwabaphambili Ama-SARM UK isitolo - The Isitolo se-SARM.
I-Andarine (i-S-4)
I-SARM yomlomo engeyona eyomlomo, Andarine iyi-moduli ekhetha izicubu ekhetha i-androgen receptor modulator enamandla okuvuselela izitho ze-anabolic ngomthamo omkhulu kunezitho ze-androgenic. Ukusetshenziswa kwe-S-4 akuhlotshaniswa nokwanda kwamazinga e-estradiol. Akucindezeli ngokuphawulekayo i-hormone ekhuthaza i-Follicle ne-Luteinizing hormone. Lokhu kusho ukuthi u-Andarine angakhuphula ubukhulu bethambo nemisipha ngaphandle kokuholela kunoma yimuphi umthelela omubi kwi-prostate.
Isetshenziswa kakhulu umjikelezo wokusika i-SARM, i-Andarine iyanciphisa lipoprotein lipase nokugcinwa kwamanzi ngenkathi kukhula isisindo semisipha. Lokhu kusikisela ngokusobala ukuthi i-S-4 iyinhlanganisela emangalisayo yokwandisa ukulahleka kwamafutha ngenkathi inyuka kancane noma igcina ubukhulu bemisipha. Ngaphezu kwalezi zinzuzo, i-S-4 ibuye ikhombise ukusebenza ngempumelelo ngokunciphisa ubungozi bokuqhekeka kwamathambo ngokugcina isilinganiso senzuzo yethambo ohlangothini olungezansi nokukhulisa amandla emisipha ngasikhathi sinye.
I-S-4 ifakwe kahle kakhulu nge-GW-501516 neMK-677. Thenga i-Andarine manje!
I-Ostarine (MK-2866)
Ostarine, eyaziwa nangokuthi i-Ostabolic, yi-SARM ehlotshaniswa nokuthuthuka okukhulu ekusebenzeni komzimba, isisindo somzimba esinciphile, nokuzwela kwe-insulin. Emhlabeni wokwakha umzimba, i-Ostarine yaziwa kakhulu ngezinzuzo zayo phakathi nezigaba zokukhwabanisa nokubuyisela kabusha. I-MK-2866 iyinhlanganisela emangalisayo ngenxa yemiphumela yayo yokuhlukanisa izakhi ezingasiza abasebenzisi ukuthi balahlekelwe ngamafutha omzimba futhi bathole ubukhulu bemisipha ngasikhathi sinye.
I-Ostarine ifakwe kahle kakhulu ngamakhompiyutha afana ne-GW-501516, S-4, S-23, ne-Testolone. Thenga i-Ostarine manje kusuka kokuhamba phambili Ama-SARM UKisitolo - The Isitolo se-SARM.
I-Ligandrol (LGD-4033)
Obeye aziwe njengo I-Anabolicum, I-LGD-4033 iyi-SARM emangalisayo yokusika, ukukhwabanisa, ukuzuza amandla, noma izigaba zokubuyisela kabusha. Enye yama-SARM anamandla kakhulu, i-LGD-4033 isiza abakhi bomzimba ukuthi bazuze amandla amakhulu nokuzuza kwemisipha okungagcinwa kube lula futhi isikhathi eside. Kungcono ukuvala izikhala phakathi kwemijikelezo futhi kuvimbele ukonakala kwethambo. Le SARM inamandla okuphatha ukuzivocavoca okunamandla ngamaphesenti angama-40 kuye kwangama-50 avumela abantu ukuthi balindele ukuhlanzeka ngemithambo ehlanzekile, enzima, nengcono ngesikhathi sokusika.
I-LGD-4033 ifakwe kahle kakhulu nge-MK-2866, MK-677, ne-S-4. Thenga i-LGD-4033 ukusuka Isitolo se-SARM- isitolo se-inthanethi esithandwa kakhulu emhlabeni sama-grade grade SARMs.
S-23
Le SARM yomlomo engatholakali ngomlomo yaziwa kakhulu emhlabeni wokwakha umzimba njengenye indlela engcono kune-S-4 ekhuthaza ukuqina kwemisipha. Waziwa ngo "Ubaba Omkhulu”Yama-modulators we-androgen receptor akhethiwe, i-S-23 ihlose ukwamukela amakhemikhali ethanjeni nasesicutshini.
Uma ihlanganiswe nokudla okuhle nokuzivocavoca okukhulu, le SARM isiza abasebenzisi ukuthi bazuze imisipha ehlala isikhathi eside futhi engakaze ibonwe nokuzuza. Ngokusebenzisa le SARM isikhathi esiyiminyaka eyishumi kuya kwayishumi nane, abasebenzisi bangalindela ukwenza ngcono amafutha oxidisation, mafutha muscle mass, amandla, ukukhuthazela, kanye nomuzwa wenhlalakahle.S-23kuyaziwa futhi emhlabeni wezokusubatha nokufukula amandla njenge-SARM enamandla engaqeda ngokuphelele ikhathalogi ekushodeni kwekhalori futhi ithuthukise ngokuphawulekayo amazinga emisipha yemithambo, yobulukhuni, neyokomisa.
I-Cardarine (i-GW-501516)
Isidakamizwa sokuphupha somakhi womzimba, I-Cardarine (I-GW-501516) iyinhlanganisela ethandwa kakhulu futhi ephumelelayo uma kukhulunywa ngokuqhumisa amafutha angafuneki. Ukusetshenziswa kwale SARM kuhlotshaniswa nezikhathi ezincishisiwe zokululama kokuqeqeshwa kanye nokukhuphula ukukhuthazela kokuphakamisa. Zonke lezi zinzuzo ezimangazayo zenza i-GW-501516 ibe ngumjikelezo wokusika omuhle kakhulu ongathuthukisa ukusebenza ejimini ngamafushane nje amasonto ayisishiyagalombili kuya kwayishumi nambili.
Ngokusebenzisa le Peroxisome proliferator-activated receptor-β agonist, abasebenzisi bangalindela amandla athuthukisiwe, ukushiswa kwamafutha, nokulahleka kwamafutha. Ngaphezu kwalokho, le SARM inikeza ukuvikelwa okungenakuqhathaniswa emikhunjini yobuchopho kusuka ekulimaleni kwe-oxidative kanye nengcindezi ngokukhulisa ukukhula kwamangqamuzana ezinzwa. I-Cardarine ifakwe kahle kakhulu ngamakhompiyutha afana neMK-2866, S-4, MK-677, ne-Stenabolic.
Thenga i-Cardarine kokuthandwa kakhulu emhlabeni Ama-SARM UKisitolo - The Isitolo se-SARM.