Njengoba igama layo liphakamisa, i-Ibutamoren iyisidakamizwa esingeyona i-peptide esithuthukisa ukukhiqizwa kwe-hormone yokukhula ngokugqugquzela indlala ye-pituitary.
I-Ibutamoren ayisebenzi njenge-anabolic steroids, ethinta ama-androgen receptors omzimba. Esikhundleni salokho, ihlose ama-receptors ahlukene alawula ukukhiqizwa kwe-hormone yokukhula kanye nezinqubo ze-metabolic.
Njengoba i-MK-677 ingaphazamisi ukukhiqizwa kwe-testosterone, umzimba wakho awukho ngaphansi kokuphazamiseka kwe-hormonal kanye neminye imiphumela engathandeki, njengamahomoni e-steroid. Ngakho-ke, asikho isidingo sokwelashwa kwangemva komjikelezo.
Iyini Ngempela Ibutamoren / Nutrobal (Mk-677)?
I-Ibutamoren, eyaziwa nangokuthi i-Nutrobal ne-MK-677, i-agonist ekhethiwe ye-ghrelin receptor kanye ne-hormone yokukhula secretagogue. Ngenxa yalokho, kwandisa ngokuphumelelayo i-insulin-like growth factor 1 (IGF-1) kanye nokukhiqizwa kwe-hormone yokukhula.
I-Nutrobal yaqale yenzelwe ukwelapha izimo zezempilo ezifana ne-osteoporosis, ukuwohloka kwemisipha, nokukhuluphala. Le secretagogue ye-hormone yokukhula elawulwa ngomlomo iphinde ikhonjiswe ekwelapheni iziguli esezikhulile ezine-hip fracture.
Indlela Yesenzo Ye-Ibutamoren
I-Nutrobal isebenza ngokuthuthukisa ukukhululwa kwe-GHRH (i-hormone yokukhula ekhulula i-hormone). Njengoba igama layo libonisa, lena akuyona i-hormone yokukhula (GH) kodwa enye i-hormone eyikhululayo.
I-Ibutamoren iphinde ivimbele ukubonakaliswa kwe-somatostatin receptor. Ngaphezu kwalokho, ikhulisa ukubonakaliswa kwe-GHRH kuma-somatotrophs we-anterior pituitary gland. I-Nutrobal ibalulekile ekunciphiseni ukukhululwa kwe-somatostatin, into evala ukukhululwa kwama-hormone okukhula emzimbeni.
Ucwaningo lubonisa lokho I-Nutrobal, noma i-Ibutamoren, ingathuthukisa izinga lamahomoni okukhula emzimbeni. Lokhu ikwenza ngokulingisa isenzo se-ghrelin, i-hormone ekhuthaza indlala futhi ivuse umzimba.
I-MK-677 ibophezela ku-GHSR, enye ye-androgen receptors ebuchosheni. Kuyaphawuleka ukuthi i-GHSR ecushiwe ivuselela ukukhululwa kwe-hormone yokukhula ebuchosheni.
Ngokwenza lokhu, i-Nutrobal iphinde ithuthukise izici eziningana, okuhlanganisa:
- Isifiso;
- Isigqi sezinto eziphilayo;
- Inkumbulo;
- Ukuqaphela;
- Mood;
- Ubumnandi nomuzwa wenhlalakahle.
Elinye lamabhonasi eNutrobal ukuthi ithuthukisa amazinga ama-hormone okukhula ngokunganyuki okuncane emazingeni amanye amahomoni afana ne-cortisol.
Ezinye izinzuzo ezikhona zingabandakanya: ukuthuthuka kwebala, ukukhuphuka kwamandla namandla, ukukhuthazela okwandayo, ukuhlanganiswa kwamaprotheni, kanye nokugcinwa kwe-nitrogen.
I-nitrogen iyisakhi esiyisisekelo sama-amino acid anesibopho sokwenza amaprotheni. Ngakho-ke, lapho umzimba usesilinganisweni esihle se-nitrogen, unezinto zokulungisa ukulimala futhi ukhiqize amazinga adingekayo amahomoni.
Ucwaningo oluningi luye lwaphakamisa nokuthi iMK-677 ivuselele impendulo ekhuphukayo yomzimba.
Esinye isici esiphawuleka kakhulu se-MK-677 ukuthi ayiqhudelani nhlobo namazinga e-hormone yokukhula avame ukuhlotshaniswa nokuphathwa kwe-hormone yokukhula komuntu elawulwa ngaphandle. Ngenxa yalokho, ungasebenzisa i-Nutrobal ye-HGH imijikelezo, enikeza ukwanda kwe-GH pulses yemvelo. Kusho futhi ukuthi awudingi ukubhekana nemijovo ye-hormone yokukhula yomuntu ebuhlungu noma ecasulayo nsuku zonke.
Zonke lezi zinzuzo ziphakamisa ukuthi abasubathi, abakhi bomzimba, nabanye bangasebenzisa i-Nutrobal ngezinjongo ezihlukahlukene. Kunezinzuzo eziningi, kusukela ekukhuleni kwemisipha kuya ekuqhekekeni.
Izinzuzo ze-Mk-677
Izinzuzo eziyinhloko ze-MK-677 ukwanda kwe-hormone yokukhula kanye namazinga e-IGF-1. I-hormone yokukhula isiza ngokulungiswa kwezicubu, ukukhula kwemisipha, kanye ukulahlekelwa kwamafutha. I-IGF-1 ibalulekile ekukhuleni kweseli nokuvuselelwa kabusha.
Ithuthukisa Ukwakhiwa Kwemisipha
I-Ibutamoren iphumelela kakhulu ekukhuthazeni ukwanda okuphawulekayo kwamazinga omzimba obunzima. Iphinde ibonise ukusebenza kahle okufanayo ekukhuliseni isisindo somzimba, amandla emisipha, kanye nencazelo yemisipha ngenkathi kunciphisa amafutha omzimba.
Yehlisa Ukuwohloka Kwemisipha
I-Ibutamoren iyisidakamizwa esihle kakhulu sokubuyisela ukulahlekelwa kwesisindo esibangelwa ukudla okungenzeka ngokulahleka kwemisipha. Ngaphezu kwalokho, i-Nutrobal ingathuthukisa kakhulu isivinini sokuhamba namandla emisipha. Kungase futhi kunciphise inani lokuwa ezigulini esezikhulile ezine-hip fracture.
Ithuthukisa Ikhwalithi Yokulala
Ucwaningo lwesayensi luye lwabonisa ukuthi i-Ibutamoren ingaba nomthelela omuhle ubude besikhathi sokulala se-REM kanye nekhwalithi yokulala jikelele. Ngendlela efanayo ne-ghrelin, igcina isigqi se-circadian isheke futhi ikhuthaza ukulala okungaguquki nokungaphazanyiswa. Ngenxa yalokho, labo abathatha i-Ibutamoren ngokuvamile bangathola ukuthi bangalala ngokuzwakalayo futhi bazizwe beqabulekile ngemva kokuvuka.
Ithuthukisa Ukuphila Isikhathi Eside
I-Ibutamoren ingathuthukisa amazinga e-IGF-1 kanye ne-hormone yokukhula emzimbeni, enezinzuzo eziningana. Ukuntuleka kwe-IGF-1 kukhona kulabo abanezinkinga ze-hormone yokukhula futhi kungaholela emathanjeni aphukile, imisipha ephansi, kanye namazinga e-lipid ashintshiwe. Ilungele abantu abahlangabezana nokwehla kwesisindo somzimba kanye nokuphuma kwe-GH. Ngisho nalabo abanamazinga ajwayelekile bangazuza kwezinye zezinzuzo ze-Ibutamoren.
Kuthuthukisa ukuqina kwamathambo
Amathambo anempilo abalulekile, kungakhathaliseki ubudala, isisindo, noma amakhono okugijima. Amathambo aqinile, abuthaka, noma anezimbotshana angaholela ekulimaleni okuvela ezingozini ezibonakala zincane futhi, kanye nokuba buhlungu nokunciphisa inqubekelaphambili yakho yezemidlalo, kungaba isandulela sezinkinga ezifana ne-osteoporosis. I-hormone yokukhula isebenza kahle kakhulu ekwandiseni ukungena kwamathambo futhi ekugcineni ubukhulu bamathambo.
Phakathi ku ukutadisha abesifazane asebekhulile abane-osteoporosis ekhona, U-Emily Krantz, MD, ubike ukuthi: "Eminyakeni eminingi ukwelashwa kumisiwe, abesifazane abaphathwa nge-hormone yokukhula basabhekana nobungcono bamathambo futhi banciphisa nengozi yokuqhekeka."
Imiphumela ye-Nootropic
Izenzo ze-Nutrobal ku-ghrelin receptor eyaziwa kahle ukuthi zinemiphumela ye-nootropic. Zinomthelela omuhle ekusebenzeni kobuchopho ekukhuthazeni, inkumbulo, nokudala. Iqiniso lokuthi i-Nutrobal iphinde ithuthukise izinga lokulala nobude besikhathi nakho kuyasiza; lokhu kungenxa yokuthi zombili zibalulekile ekusebenzeni okuthuthukisiwe kwengqondo.
Ukwelapha Ukushoda KweHormone
I-MK-677 ithuthukisa i-IGF-1 namazinga e-hormone okukhula ezinganeni ezinokuntuleka kwe-GH. Iphinde yelapha i-Insulin-like Growth Factor binding protein 3 (IGFBP-3) kulezi zingane. Lezi zinzuzo zenzeka ngaphandle kwemiphumela emibi ku-thyrotropin, i-prolactin, ne-glucose.
Isheshisa Ukuphulukiswa Kwesikhumba
Enye inzuzo ye-MK-677 ongayithola ukuphulukiswa okusheshayo ngemva kokuhlinzwa noma isilonda. I-Nutrobal ibonisa isithembiso esihle kakhulu sokuphulukisa ukulimala okudala nokubeleselayo. Kuyasiza futhi ukuqinisa isikhumba esixegayo ngaphandle kwemisipha ephulukisayo, amathambo, nemigqa futhi kusebenza ngokulinganayo ekwelapheni amanxeba nokuvuselela izicubu.
Ukwanda kwe-collagen kunesibopho salokhu, futhi i-MK-677 ingase ifanele ukucatshangelwa uma uthola isikhathi sakho sokutakula sihamba kancane njengoba ukhula. Thenga ama-SARM athengiswayo manje futhi uzizwele umehluko ngokwakho!
Kuthuthukisa Ukwehliswa
Abasebenzisi abaningi beMK-677 bangakhathazeka ngokuthi umkhiqizo owandisa i-ghrelin ("indlala hormone") ungasiza kanjani lapho befuna ukuhlala kushodlova lwamakhalori.
I-powerhouse elinganiselwe, i-ghrelin, ikhuphula indlala futhi ikusiza ukuthi udle ama-calories engeziwe. Ngesikhathi esifanayo, idlala indima ebalulekile ekulawuleni ukusetshenziswa kwamandla (amafutha agciniwe).
Uma ukhethwe ngokuphepha futhi uhambisana neseluleko sikadokotela wakho, akukho lutho olungalungile ngokungeza ezinye izinhlanganisela ukulwa nale miphumela futhi kukusize ukhawule izifiso zendlala. Funda okuthunyelwe kwethu ku-stacking ukufunda kabanzi ngokuhlanganisa ngokuphephile izithasiselo zemiphumela eminingi.
Kodwa-ke, izakhiwo zokwakha imisipha zikaNutrobal zikusiza ukuthi ugcine izinzuzo ozitholile kanzima, noma kusilele ikhalori.
Yehlisa Imithelela Yokumosha Nitrogen
Inzuzo yokugcina ye-Ibuatmoren yukuthi ingaba negalelo ekubuyiseleni ukumoshwa kwe-nitrogen emzimbeni.
Ukumoshakala kwe-nitrogen kwenzeka lapho ukukhishwa kwe-nitrogen yomuntu kudlula inani alithathayo futhi kubangela isimo se-catabolic emzimbeni. Lokhu kuzoholela ekulahlekelweni kwamafutha nemisipha ngokuhamba kwesikhathi futhi akulungile kulabo abafuna inqwaba! I-Ibutamoren ibuyisela ibhalansi ye-nitrogen kulabo abanamazinga aphansi futhi igcine ngokulingana.
Imiphumela Eseceleni ye-Mk-677
I-Prolactin Effects
I-Ibutamoren ingase ikhulise amazinga e-prolactin. I-Prolactin iyi-hormone ehilelekile ekukhiqizeni ubisi kanye nokulawula amasosha omzimba. Esifundweni samagundane, i-Ibutamoren yanda amazinga e-prolactin ngemva kwezinsuku ze-14 zokwelashwa.
Imiphumela Yamathumbu
I-Ibutamoren ingase ibangele imiphumela emibi yesisu njengesihudo, isicanucanu, nokuhlanza. Esifundweni samagundane, i-Ibutamoren yabangela imiphumela emibi yamathumbu ngemva kwezinsuku ze-14 zokwelashwa. Kodwa-ke, akucaci ukuthi i-Ibutamoren inomkhiqizo ofanayo kubantu.
I-Hormone Regulation
I-Ibutamoren ingashintsha amazinga e-hormone. Esifundweni samagundane, i-Ibutamoren yanda i-hormone yokukhula, i-IGF-1, namazinga e-prolactin ngemva kwezinsuku ze-14 zokwelashwa. Kusanqunywa ukuthi i-Ibutamoren inomphumela ofanayo kubantu. I-Ibutamoren ivame ukubekezelelwa kahle, kodwa idatha yokuphepha yesikhathi eside ayikho. Ayikho imiphumela emibi eyaziwayo ehlobene nokusetshenziswa kwe-Ibutamoren.
I-Hypo-Pituitary Desensitation
I-Ibutamoren ingase ibangele i-hypo-pituitary desenitisation. Yilapho indlala ye-pituitary ingazwela kakhulu kuma-hormone okukhula. Esifundweni samagundane, i-Ibutamoren yabangela ukuthuthumela kwe-hypo-pituitary ngemva kwezinsuku ze-14 zokwelashwa. Noma kunjalo, kusanqunywa ukuthi i-Ibutamoren inomphumela ofanayo kubantu.
I-Nutrobal Half-Life
Ukuphila kwesigamu se-Nutrobal cishe amahora angu-4 kuya kwangu-6. Ngakho-ke, ochwepheshe batusa umthamo we-Nutrobal kabili ngosuku. Abasebenzisi besilisa bangathatha imithamo emibili elinganayo yokuhlukanisa ye-12.5mg kanye ekuseni futhi futhi kusihlwa. Abasebenzisi besifazane bangathatha phakathi kuka-2.5 no-7.5mg, kanye ekuseni kanye kanye kusihlwa.
I-Nutrobal ibekwe kahle kakhulu ngama-SARM afana Ostarine (MK-2866), Andarine (S-4), I-LGD-4033, Futhi I-Cardarine (GW-501516). Kungcono kakhulu ku-a ukusika isitaki umjikelezo no-Ostarine, S-4, noCardarine. Ingase futhi inqwabelene nge-Ligandrol ukuze uthole izinzuzo zesisindo somzimba. Ngomjikelezo wokusika, i-Nutrobal ingapakishwa kumithamo emibili ehlukanisiwe ye-12.5mg nsuku zonke. Amadoda kufanele asebenzise i-20mg Cardarine nsuku zonke nayo ngamaviki angu-10-14. Ngaso sonke isikhathi hlola futhi ulandele imihlahlandlela endaweni yangakini njengoba imithetho yalezi zithasiselo iyehluka.
Kunconywa njalo ukuthi hamba uphephile ngokwelashwa komjikelezo weposi. Ukuze uthole lokhu, cabanga ngokusetshenziswa kwe Amalebhu Akhiwe Ngomzimba SARMs Cycle Support 90 Capsules ukusekelwa komjikelezo. Ukusetshenziswa kwe Amalebhu Wokwakha Omzimba Ama-PCT 90 Amaphilisi kwePost Cycle Therapy kuphakanyisiwe. Thenga ama-SARM ukuthengiswa manje.
Indlela yokusebenzisa i-Ibutamoren
I-Nutrobal ifakazelwa ngokomtholampilo ukuthi iyasebenza futhi ayinangozi. Inikeza imiphumela engcono kakhulu ngaphandle kwemiphumela engemihle. Isikhathi esingcono kakhulu sokuthatha i-MK-677 ngaphambi kokulala.
Awudingi ukukhawulela ukwamukelwa emijikelezweni, kodwa uma unokukhathazeka, ubude besifundo esinconyiwe ngamaviki ayi-12 ngezikhathi zamaviki ayi-6 kakhulu. Umuthi ufanelekile kokubili ukuzuza okukhulu nokushiswa kwamafutha.
Isilinganiso se-Mk-677
Ngokusho kochwepheshe, umthamo ophelele ngu-20 kuya ku-30 mg. Ukweqa umthamo ngaphezu kwe-30 mg akunikezi umphumela owengeziwe oshiwo.
Lapho uthatha i-Ibutamoren, ubude besifundo bubaluleke kakhulu kunomthamo wansuku zonke. Ngakho-ke, ukusetshenziswa kwe-MK-677 kumele kube isikhathi eside. Amazinga e-hormone okukhula akhuphuka kancane kancane phakathi namasonto ambalwa.
Abakhi bomzimba abangochwepheshe batusa ukuthatha i-Ibutamoren kumithamo elandelayo yansuku zonke, ngokuya ngomsebenzi owenziwayo:
- Ukwanda kwemisipha - 30 mg.
- Ukushiswa kwamafutha - 20 mg.
- Ukuphulukisa ukulimala nokululama - kusuka ku-10 kuye ku-20 mg.
- Kwabaqalayo abangenalwazi nge Ama-SAR noma ezinye izidakamizwa, eziqala ngesilinganiso esincane se-10 mg siyanconywa, kungakhathaliseki ukuthi yiziphi izinhloso.
Ukuqapha Okufanele Kuthathwe
Kubalulekile ukuqaphela lapha ukuthi i-Nutrobal ayelulekwa ukuthi isetshenziswe kwabesifazane abakhulelwe noma abancelisa ibele, futhi akufanele isetshenziswe izingane kanye/noma labo abaneminyaka engaphansi kuka-21. Labo abangezwani nezithako zento esebenzayo noma ezingasebenzi kufanele futhi bakugweme ukusebenzisa i-Nutrobal. Ukusetshenziswa kwalesi secretagogue se-GH kufanele ngaso sonke isikhathi kwenziwe kuphela ngemva kokuncoma kwezokwelapha.
Khumbula ukuthi imithamo yalo muthi othuthukisa ukusebenza kwezidakamizwa akufanele neze ushintshwe ngaphandle kokunconywa kwangaphambili kwezokwelapha. Ngaphansi kwezimo akufanele ukwandise umthamo wakho ngaphandle kokuncoma kwezokwelapha njengoba lokho kungaholela ekusetshenzisweni ngokweqile noma ekuhlukunyezweni.
I-Mk-677 vs. Hgh
I-MK-677 iyi-secretagogue ye-hormone yokukhula esebenza isikhathi eside okufanele uyithathe ngomlomo. Ilingisa ukukhula okubonwa ku-GH. Ukusebenzisa i-MK-677 nsuku zonke kunamandla okuphakamisa amazinga e-GH ne-IGF1 ngokuphawulekayo kubantu abasha abanempilo ngaphandle kokubangela imiphumela emibi kakhulu.
I-Human Growth Hormone, eyaziwa nangokuthi i-Somatropin ngesimo sayo esigcwele, i-hormone ekhuthaza ukukhula phakathi kwazo zonke izicubu zomzimba womuntu. Lokhu kuhlanganisa ukuvuselelwa kwamathambo nokukhiqizwa kwamangqamuzana. I-HGH ibalulekile ekugcineni izicubu ebuchosheni bethu nezinye izitho ezinempilo.
I-Mk-677 Ngesikhathi Se-Pct
I-PCT isikhathi ngokushesha ngemva kokumisa i-AAS futhi ingase ibandakanye uhla lwezidakamizwa noma ukuziphatha ukuze kube lula ukushintshela ekuyekiseni ukusebenzisa i-PIED.
Ungasebenzisa i-MK-677 ngesikhathi se-PCT ukukusiza ukuthi ubuyele emuva futhi uhlale unamandla. Uzoqaphela ukuthi cishe njalo ingxenye yakho Izitaki ze-PCT—futhi ngesizathu esihle.
Lapho Ungayithenga I-Mk-677
Njengoba ukwazi ukubona, iMK-677 ingaba ishintsho somdlalo esimisweni sakho sempilo nokuqina. Amandla ayo okukhulisa isisindo nemisipha nokuqinisa umzimba kuyahlaba umxhwele ukusho okuncane.
Isitolo se-SARM UK uthembisa ukuthi uzokwazi ukuthenga i-Nutrobal yekhwalithi ephezulu kakhulu etholakala ku-inthanethi. Ngokuhlala uphethe ucwaningo lwebanga le-MK-677, siqinisekisa ukuthi uzothola imikhiqizo ehamba phambili.
Khumbula, imakethe ye-Selective Androgen Receptor Modulators ngezinye izikhathi ithembekile. Lokhu kungenxa yokuthi ama-SARM avinjelwe izinhlangano ezifana ne-WADA, i-USADA, ne-UKAD emiqhudelwaneni eminingi yezemidlalo.
Hlala uqaphile futhi ucwaninge ngaphambi kokwenza izinqumo, ikakhulukazi mayelana nempilo yakho. Xhumana nochwepheshe ukuze uthole imvume nezeluleko ukuze uthole umphumela ongcono kakhulu ongakhona. Kuhlale kungcono ukuhamba nomholi wemboni, okungenye yezizathu zokuthi kungani i-SARMs Store inamakhasimende abathandayo abavela emhlabeni wonke.