Izinkampani ezithaka imithi zandisa ukunambitheka kwazo ngokukhiqiza inqwaba yezidakamizwa zemithi nezemidlalo. Abantu abaningi bakholelwa ukuthi sekulula ukwenza imali yokwelapha izifo ezahlukahlukene kubuchwepheshe obusha. Bambalwa abantu abaziyo ukuthi iningi lemikhiqizo emisha eyavela emakethe ngemuva kuka-2000 yintuthuko yososayensi bekhulu lama-20. Ama-SAR ithandwa kakhulu kwezemidlalo manje. Lezi zimali zakhiwa kuma-40s wekhulu elidlule lokwelapha izifo ezihambisana nokushoda kwe-testosterone namanye ama-hormone. Futhi, lezi zidakamizwa zazisetshenziselwa ukuqeda imisipha nokukhula nokukhula kokubambezeleka ezinganeni.
Isifinyezo Ama-SAR ithole igama elinjalo ukuze kube lula kumthengi futhi imele ama-Selective Androgen Receptor Modulators. Ngokusebenza, zihluke kakhulu kuma-hormone agents, ngaphandle kokungabikho kwemiphumela emibi. Inzuzo enkulu yama-modulators umphumela wawo ekukhuleni nasekuthuthukiseni kwesisindo semisipha.
Ahluke kanjani ama-SAR kuma-anabolic steroids?
Umsubathi ngamunye usebenzise izinsiza zomzimba ezahlukahlukene kulo lonke umsebenzi wakhe. Zonke izidakamizwa nezengezo zemidlalo ziyehluka ngokwakhiwa, izakhiwo futhi, nakanjani, ukuba khona kwemiphumela emibi. Kusukela kukhishwe i- Ama-SAR, baye baba usizo oluthandwa kakhulu. Manje wonke umsubathi wesine ukhetha i-androgen receptor modulators, ngokungafani nenkolelo evamile. Ngaphambi kokukhiqizwa kwalezi zimali, ama-hormone e-anabolic asetshenziswa ngenkuthalo. Kunzima kakhulu kubaqalayo ukukhetha phakathi kwe-steroids ne Ama-SAR ukulahleka kwamafutha noma ukuzuza kwemisipha. Lokhu kungenxa yemininingwane encane ngemikhiqizo enjalo.
Izici ezihlukanisayo zamaSARM zifaka lezi zinto ezilandelayo:
- Ukuntuleka kokunambitheka esifundweni nemiphumela efana nokuqoqwa kwamanzi.
- Akucindezeli ukukhiqizwa kwe-testosterone yemvelo.
- Ukwelashwa kokuvuselela ngemuva kwenkambo akudingeki.
- Kungenzeka ukuthi uthole isisindo semisipha ngaphandle kokujova.
- Akuguquki ku-dihydrotestosterone.
- Ingahlanganiswa nezinye izidakamizwa, kungakhathalekile ukuthi zakhiwe kanjani.
- Intengo engabizi, ukuba semthethweni, akukho ukuhlolwa kwe-doping.
- Ukuqinisa amasosha omzimba.
Kubalulekile ukukhumbula ukuthi ungasebenzisa ama-SARM kungakhathalekile ubulili bakho noma umgomo wakho. Lezi zibhebhe zibe yizinsiza ezisemqoka kwezemidlalo nakwezokwelapha. Abaqalayo abaningi babuza umbuzo ofanayo- yini engcono kakhulu ongayisebenzisa kwezemidlalo? Lo mbuzo uzohlala ungaphenduliwe; ngoba umuthi ngamunye unezimfanelo ezinhle nezimbi, ukukhetha kuhlala kuye kumdlali.
Izinhlobo zama-SARM
Noma iyiphi Ezemidlalo isitolo sinezinhlobonhlobo zezidakamizwa nezengezo futhi, Ama-SAR. Umthengisi unikeza umthengi umkhiqizo onenzuzo enkulu kubo, kepha umsubathi kufanele akuqonde izinhlobo zama-SARM ukukhetha okulungele kangcono kubo.
Kunezinhlobo ezimbili eziyinhloko zama-modulators:
- Ama-steroid athuthukiswa ekuqaleni kwekhulu leminyaka elidlule futhi asetshenziswa isikhathi eside kwezokwelapha kwaze kwaba ngama-90s wekhulu lama-20. Ziyafana nokusebenza kwe-steroids kepha zinemiphumela emibi kakhulu.
- Iqembu elingeyona i-steroidal linamagciwane emidlalweni yezobuchwepheshe. Ithuthukisa ukusebenza komzimba ngaphandle kokuphazamiseka kwe-hormonal futhi inemiphumela efana nokubonakaliswa kwe-estrogenic. Uma umgijimi ethatha isinqumo sokusebenzisa izidakamizwa zalolu hlobo kwezemidlalo, kufanele azijwayeze wonke ama-nuances futhi aqonde ukuthi yibaphi abakhiqizi bama-SARM abathandwa kakhulu futhi abafunwa kwezemidlalo .
MK2866. Lokhu kuhamba phambili uhlobo lwe-SARM lokho sekufundwe. Kuyaziwa nangokuthi i-Ostarine. Ucwaningo lukhombisile lokho I-MK-2866 isebenza kahle kakhulu ekwakheni isisindo semisipha, futhi iyazuzisa njengoba ingenayo imiphumela emibi eminingi. Nge-MK-2866, ungalindela ukukhulisa imisipha yakho njalo ngenyanga.
YK11. Itholwe nguYuichito Kanno futhi ingenye ye- ama-SARM amahle kakhulu njengoba kuzuzisa kakhulu ukulahleka kwamafutha nokwakhiwa kwemisipha ngaphandle kokuhlushwa imiphumela emibi efana nokulimala kwesibindi noma umfutho wegazi ophakeme.
I-RAD140. Yaziwa nangokuthi i-Testolone futhi ingenye yama-SARM anamandla kakhulu atholakala emakethe. Ukhulisa ubukhulu bemisipha namandla. Iphinde ikhulise i-libido.
I-LGD4033. Nayi enye uhlobo lwe-SARM lokho kuqondakala kangcono. AbakwaLigand Pharmaceuticals baqale ukuyithuthukisa, sebenze izivivinyo eziningi zabantu, futhi kwafakazela ukuthi bangumuthi othakazelisayo.
Isifundo esinempilo abesilisa abathathe i-LGD4033 izinsuku ezingamashumi amabili nanye bakhombisile ukuthi lesi sidakamizwa sandisa kakhulu isisindo somzimba esinciphile. Umphumela ohlangothini kuphela ukucindezelwa kwesikhashana kwe-testosterone. Ukuthatha i-milligram eyodwa ye-LGD4033 ngosuku kukhiqiza ukukhula okukodwa okubalulekile kwemisipha, kepha uma umthamo uphakama, imiphumela iba ngcono.
SR9009. Lokhu kungenye ethandwayo uhlobo lwe-SARM. Kamagundane, lokhu kuye kwabonwa ukukhuthaza ukukhula kwemisipha ye-mitochondrial, ukunciphisa ukuvuvukala, ukukhulisa ukukhuthazela, nokusiza ukulahla amafutha omzimba. Noma kunjalo, amagundane anikezwa SR9009 njengomjovo. Uma ithathwa ngomlomo, ingahle ingabi nomphumela ofanayo njengoba inokutholakala okungu-2% futhi izosuswa ohlelweni ngokushesha nje lapho uyithatha.
MK677 Lokhu kungaphezulu kwe-hormone yokukhula, futhi esikhundleni sokucindezela ama-hormone okukhula emzimbeni wakho, kuyangeza kubo. Nge-MK677, ungalindela ukwanda okusheshayo kwendlala, ukukhiqiza okwandisiwe, nokulahleka okukhulu kwamafutha.
S-23. Kuyinto engeyona i-steroidal uhlobo lwe-SARM esebenza ngomlomo futhi ibophezela ngempumelelo kuma-androgen receptors, okuholela ekukhuleni kwesisindo semisipha nokwehla kwesisindo samafutha.
Ungawasebenzisa kanjani ama-SARM ngokufanele?
Eziningana izinhlobo ze-SARMs ingasetshenziselwa izinhloso zemidlalo. Ngokuya ngohlobo lomuthi kanye nokusebenza kwawo, ungabala ngokunembile umthamo futhi uzuze impumelelo ezinyangeni ezimbalwa nje zokusetshenziswa.
Kubalulekile ukukhetha umuthi ngqo ngenhloso nesipiliyoni:
- I-Ostarine (MK-2866) ilungele abaqalayo; isebenza ngokushesha nangobumnene ngaphandle kokuthinta kabi uhlelo lwamahomoni nezempilo. Lokhu uhlobo lwe-SARM akuyona ingozi, kepha ingasheshisa ukuqashwa kwemisipha futhi yenze inkambo yokumisa ngokusebenza kahle okukhulu.
- Kwabachwepheshe, iLigandrol (LDD-4033) izohlinzeka ngokukhula kwemisipha, ikhulise amandla wamandla, futhi ivimbele ukukhathala komzimba. Ziyizidakamizwa ezinamandla; ngakho-ke, zivame ukusetshenziswa ngabadlali bezemidlalo. Umthamo ulula kakhulu, iphilisi elilodwa kuphela ngosuku lomuthi ngamunye ngemuva kokudla.
- Ukwehla kwesisindo kungakhathalekile ukuthi ubulili nobani ngokweqile, iCardarine (GW501516) ilungele ukushiswa kwamafutha okusheshayo. Abaningi abazi ukuthi bathathe kanjani I-SARMs bese ubale isilinganiso sabo. Okubi nakakhulu, abantu abaqondi ukuthi akukufanele ukulinda imiphumela nje ngokuthatha iphilisi. Ukwehlisa isisindo esiningi, udinga ukuthuthukisa uhlobo olukhethekile lokudla nokuvivinya umzimba. Abasubathi basebenzisa lesi sidakamizwa ngesikhathi somiswa ukuze bathuthukise ukukhululeka kwemisipha.
Uyacelwa ukuthi uqaphele ukuthi imiphumela emibi isuswa ngokuphelele uma usebenzisa Ama-SAR. Kepha uma umgijimi engawunaki umthamo futhi awusebenzise isikhathi esingaphezu kwamasonto ayi-12, kungenzeka ukuphazamiseka okuncane emsebenzini wonke womzimba.
Uwasebenzisa kanjani ama-SARM?
Different izinhlobo zama-SARM ingasetshenziselwa ukufeza noma yiziphi izinhloso zokuzuza isisindo, ukwehlisa isisindo, ukukhuthazela nokuzuza kwejubane / amandla, nokuningi.
Inhlanganisela elungile yeziningana Ama-SAR kuzokuvumela ukuthi uzuze i- best Imiphumela.
Ngokuvamile, ama-SARM asebenzisa umjikelezo ihlala kumaviki ayi-12 kuye kwayi-16, kuya ngokuthi yikuphi uhlobo lwe-SARM ukhetha.
Kunezimo eziningi ezikhona zokusebenzisa ama-SARM:
- The Ama-SAR inkambo ithandwa kakhulu njengebhuloho okuthiwa liphakathi kokusebenzisa ama-anabolic steroids nokungalahlekelwa yiyo yonke imiphumela yezifundo.
- Kusetshenziswa inkambo yama-SARM ngesikhathi sokwelapha ngemuva kokufunda.
- Ukusetshenziswa kwama-SAR kumjikelezo we-anabolic steroid ukukhulisa imiphumela ye-steroids.
- Usebenzisa nje ama-SARM ukufeza izinhloso zakho ekusebenzeni kwakho.
Ama-SAR babe okukhulu izinzuzo ukuze kudliwe umuntu ojwayelekile, futhi lezi zinzuzo zibalulekile. Ama-SAR cishe iyona kuphela indlela ephephile yokwandisa ukusebenza kwakho kwezemidlalo.
Izinzuzo zamaSARM
Ama-SAR asebenza kakhulu njenge-steroids ngaphandle kokubangela imiphumela emibi engafuneki engabangelwa yi-steroids.
Ngaphandle kwalokho, ama-SAR anezinzuzo eziningi:
- Indlela yomlomo yokuphatha.
- Imiphumela emihle ifaka ukuthatha i-testosterone (ukwanda kwe-libido, ukuqinisa amalunga nemisipha, ukushisa amafutha, ukukhula kwesisindo somzimba esinciphile, njll.)
- Akukho ukuguqulwa ku-DHT (i-dihydrotestosterone, akunankinga ngokukhula kwezinwele zomzimba nokulahleka kwezinwele zekhanda).
- Ayiguqulwa ibe yi-estrogen.
- Akuyona into enobuthi esibindini, ngokungafani nezinhlanganisela ze-methylated ezifana nama-prohormones nama-steroids omlomo.
- Awukho umphumela ekukhiqizeni kwakho i-testosterone.
- Kusemthethweni ngokuphelele.
Ama-SAR angaba ngabasizi abakhulu ekufezeni izinhloso zakho zokwakha umzimba. Kodwa-ke, kubalulekile ukugwema ukuzisebenzisa ngokweqile futhi usebenzise ukuqonda lapho ukhetha ifayela le- ama-SARM amahle kakhulu kwakho.
Njenganoma iyiphi into yokwenziwa, amandla emiphumela emibi akhona. Ubungozi buphansi kakhulu kunezinye izindlela ezifana ne-testosterone, kepha isekhona.
Khumbula ukuthi awukho umzimba osemthethweni olawula ikhwalithi yama-SARM. Uma ukhetha ukuwamukela ukuze ahlangabezane nezinhloso zakho, funa abakhiqizi abanesithunzi nababuyekezwa kahle