I-GW-501516 (Cardarine)
Emhlabeni wokwakha umzimba, i-GW-501516 (Cardarine) iyinhlanganisela engavamile enekhono elingenakuqhathaniswa lokuthatha amandla nokukhuthazela emazingeni ahluke ngokuphelele. Ngaphezu kwalokho, ukusetshenziswa kwalesi sengezo sokwakha umzimba kuhlotshaniswa nokulahleka kwamafutha nokuzuza kwemisipha kwabesilisa nabesifazane.
Enye yezinzuzo ezinkulu ze I-Cardarine amandla ayo okuncibilikisa amafutha kalula futhi ngokushesha ngenkathi engeyona eyokuphamba. Lokhu kusho ukuthi ungalindela kakhulu ukulahlekelwa amanoni anesisu esiswini nawama-visceral ngenkathi usabambelele kwimisipha eqinile futhi oyisebenzele kanzima. Ngaphandle kwalokhu, ungathatha kalula ukusebenza kwakho kokuzivocavoca kumazinga angakaze abonwe.
Yini i-Cardarine?
I-GW-501516 (Cardarine)i-agonist ye-Peroxisome Proliferator Activated Receptor δ (PPARδ) ithathwa ngabaningi njengesinye sezidakamizwa ezihamba phambili zokusika, ikakhulukazi uma kukhulunywa ngamafutha anenkani esiswini nawama-visceral.
Kuthuthukiswe ekuqaleni kwawo-1990, iCardarine (GW-501516) ivimbela ukukhuluphala, ithuthukise imetabolism, inyuse ukukhula kwemisipha, futhi ithuthukise ukushiswa kwamafutha. Iphinde ivimbele imikhumbi yobuchopho ekucindezelekeni nasekulimaleni ngaphandle kokwelapha ukuvuvukala okungapheli nokuqina kwe-insulin okubangelwa ukukhuluphala.
ICarardarine isebenza namaqembu e-receptor kusiza sokwamukela se-PPAR futhi ihlanganyela ekusebenzisaneni ne-enzyme ye-PGC-1α. I-GW-501516 ixhumana nabo ngokuphathwa kabi kofuzo njengomphumela wokusebenzisana namahomoni ama-steroid nama-thyroid alawula ukukhuluma kofuzo njengoba kuhlotshaniswa nokusetshenziswa kwamandla.
Imiphumela yeCarararine
I-Cardarine ingesinye sezidakamizwa ezimangalisa kakhulu ukuzwa izinzuzo ezinhle kakhulu ze-cardio lapho usebenzisa le nhlanganisela. Imiphumela yeCarardarine ifakazela ukuzuzisa bobabili abasanda kuqalwa kanye nabagijimi abaphambili, ngakho-ke wonke umuntu osebenzisa le nhlanganisela enamandla angalindela ukwanda okukhulu emandleni abo okuziqeqesha kanzima nangaphezulu. Amandla angenakuqhathaniswa weCarardarine angalinganiswa neqiniso lokuthi abasubathi abasebenzisa iTrenbolone, i-steroid edume ngemiphumela yayo emibi, bathole izinzuzo ezinkulu lapho besebenzisa i-GW-501516.
Iklanyelwe ngokuyinhloko ukwelapha isifo sikashukela, ukukhuluphala ngokweqile, impilo yenhliziyo, nezinkinga ze-lipid, iCardarine inamandla okuthuthukisa kakhulu amazinga e-cholesterol. Ukusetshenziswa kwalesi simoduli se-androgen receptor esikhethiwe isikhathi esingamasonto ayisishiyagalombili kuya kwayishumi nambili kuhlotshaniswa nekhono elithuthukisiwe labasubathi bokukhuthazela ukufinyelela kuzinguquko eziphakeme ngemizuzu ethile ngaphandle kokushaya isilinganiso senhliziyo esiphezulu ngesikhathi sokugijima kwabo. Lokhu kuvumela abantu ababamba iqhaza emidlalweni efana nokubhukuda, ukuhamba ngebhayisikili, nezemidlalo ukuba bakopele amazinga aphezulu enhliziyo futhi basebenze isikhathi eside ngaphandle kokuzizwa bekhathele okwenza kube yisidakamizwa esithuthukisa ukusebenza, ikakhulukazi kwezemidlalo yokukhuthazela.
Ucwaningo oluningi esikhathini esedlule lukhombisile ukuthi i-GW-501516 inamandla ayingqayizivele okwandisa imetabolism yamafutha acid. ICarardarine ikhombisa ukusebenza ngendlela efanayo ukunciphisa amathuba okukhuluphala nokuvikela isifo sikashukela sohlobo lwe-2. I-Cardarine iphinde inikeze inhlalakahle nezinzuzo zokuphila eziningi.
Enye enkulu kakhulu izinzuzo zeCarardarineukuthi ayibangeli ukukhathala komzimba noma yenze buthaka njengezithasiselo eziningi zokudla okunempilo nezokudla. Ngaphezu kwalokho, i-GW-501516 isebenza kahle kakhulu ukuqondisa kabusha izindlela ezisetshenziswa ngayo izindlela ezithile zomzimba emzimbeni. Lokhu kusho ukuthi abasebenzisi bangalindela ukusebenzisa amakhalori amaningi ukuthola amandla amsulwa. ICarardarine ikhombisa amazinga amangalisayo wokuthuthuka kokudla okunomsoco okusho ukuthi umzimba uzobeka ama-macro kanye nama-micronutrients kusuka ekudleni okuvela ekudleni okusetshenzisiwe ukuze akusebenzise kangcono kunalapho uwasebenzisa ngenye indlela.
Izinzuzo zeCarararine
Ukusetshenziswa kweCarardarine kuhlotshaniswa nokuzwela kwe-insulin okuthuthukisiwe, ukushiswa kwamafutha, ukwakhiwa kwemisipha, amandla, ukukhuthazela, namaphrofayli e-lipid. Ngaphezu kwalokho, kuhlotshaniswa nokugeleza kwegazi okuthuthukisiwe ekuthuthukiseni amazinga e-nitric oxide angavimbela amahlule egazi nezinye izinhlobo zezinkinga zenhliziyo. ICarardarine iyasiza futhi ekuthuthukiseni ukuphulukiswa kwesilonda kanye nemetabolism ephelele ye-oxidative kwizicubu ezimhlophe ze-adipose. Ngaphezu kwalezi zinzuzo, iCarardine ibuye izuzise ukukhulisa impilo ende nobungqabavu ngokuthuthukisa imetabolism yegazi nokuvimbela ukumelana ne-insulin.
I-Cardarine isiza abakhi bomzimba ngaphezulu nje kwendlela. I-GW-501516 inamandla ayingqayizivele okusiza abasebenzisi ukuqeda amafutha anenkani esiswini nawama-visceral ngamaviki amafushane ayisithupha kuya kwayishumi. Ngaphezu kwalokho, kuyabasiza ukuba basebenze isikhathi eside futhi kanzima ngaphandle kokuvunguza. Kuyiqiniso elaziwayo ukuthi isilinganiso senhliziyo yesisindo sinyuka kakhulu lapho isethi yenziwa.
I-GW-501516 ibambezela isigaba sokwehluleka nokukhathala ngezinga elibalulekile elivumela ukuthi isisindo somzimba singene kuleyo rep eyengeziwe noma ezimbili. Hhayi lokhu kuphela, i-GW-501516 isiza futhi ekunciphiseni ubude besikhathi nobuningi bezikhathi zokuphumula phakathi kwamasethi nabasindisi besisindo abathanda i-cardio ngemuva kokuqeqeshwa kwabo kwesisindo abazokwazi ukujabulela futhi bathole inani elingaphezulu lalezi zinzuzo.
I-Cardarine Nokulahlekelwa Kwamafutha
Enye yezinzuzo ezinkulu zeCarardarine uma iqhathaniswa namanye amaphilisi okulahlekelwa isisindo kanye nezithasiselo zokulahleka kwamafutha yikhono layo eliyingqayizivele lokuguqula ukungajwayelekile kwemetabolism kubantu besilisa abangaphambi kwesifo sikashukela nabakhuluphele ngokukhuthaza i-fatty acid oxidation. Ngamanye amagama, i-GW-501516 ishisa amanoni ngokwandisa ukuthathwa kweglucose ezicutshini zemisipha eziguqula imetabolism yomzimba wokushisa amafutha esikhundleni se-carbs noma imisipha yamandla. Okuhle kakhulu ukuthi konke lokhu kwenzeka ngaphandle kokubanga ukwehla kwamazinga kashukela wegazi njengezidakamizwa zesifo sikashukela. Kuyathakazelisa ukuthi uCarardarine uvimbela nokukhuluphala futhi usiza abasebenzisi ukuthi balahlekelwe ngamafutha noma ngabe bedla kakhulu.
I-Cardarine inciphisa amazinga we-triglycerides, fatty acids, low-density lipoprotein (VLDL), kanye ne-low-density lipoprotein (LDL) kanye nokukhuthaza ukwanda kwe-high-density lipoprotein (HDL-cholesterol enhle). Insalela yekhalori, i-GW-501516 ivimbela ukuqongelela kwamafutha futhi isize nasekugcineni ukubekezela kwenhliziyo. Lokhu kwenziwa ngokususa ukwanda kwezidingo zomoya-mpilo zomzimba njengoba uzuza isisindo.
I-Cardarine Nokukhuthazela
I-Cardarine ingeyesibili uma kukhulunywa ngokuthuthukisa ikhono lokuhlukanisa izakhi zomzimba. Kusebenza ngokulinganayo ukukhulisa ukuthathwa kweglucose emisipheni yamathambo, ukukhulisa ukulahleka kwamafutha, ukuthuthukisa ukukhuthazela okuphelele, nokukhombisa izakhiwo ezilwa namandla.
Ukukhushulwa okunamandla emazingeni okubekezela okuphelele ngokungenakuphikiswa kungenye yezinzuzo ezinkulu zeCardarine. Kungenxa yalesi sizathu ukuthi iningi elikhulu kakhulu labasebenzisi be-GW-501516 lisho ukuthi amazinga abo okukhuthazela akhuphuke kanjani ngamaphesenti angama-30 kuye kwangama-35 esikhathini esifushane ngemuva kokusebenzisa iCardarine.
Emkhakheni wezemidlalo okhokhelwayo, i-GW-501516 ingesinye sezidakamizwa ezithuthukisa ukusebenza ezaziwa kakhulu ukukhulisa ukusebenza kwezemidlalo hhayi ngokwakha umzimba kepha kusimo sezemidlalo. Ngaphezu kwalokho, abagijimi babike ukwanda okukhulu kwamakhono abo ukuze bacindezele phambili kakhulu amathafa okukhuthazela. Uma lokho kungagcini lapho, abasubathi nabakhi bomzimba kanye nabasebenzisi beCarardine yokuzithokozisa bangalindela izikhathi ezingcono zokuhamba nezikhathi zokugijima, isikhathi esincane sokuphumula, ukukhipha okungcono ejimini, nokusebenza okungcono embhedeni.
I-Dose Enconyiwe Ye-GW-501516 (Cardarine)
Umthamo onconyiwe we-GW-501516 (Cardarine) wamadoda ungama-20mg nsuku zonke, okungcono ngemuva kokudla nemizuzu engama-30-45 ngaphambi kokuzivocavoca okukhulu, emjikelezweni wamasonto ayisishiyagalombili kuya kwayishumi nambili. Umthamo ofanele weCarardarine wabesifazane yi-10mg nsuku zonke, okungcono ngemuva kokudla nemizuzu engama-30-45 ngaphambi kokuzivocavoca okukhulu, emjikelezweni wamasonto ayisithupha kuya kwayisishiyagalombili. Imithamo yeCarardarine ingahlukaniswa yaba yimithamo emibili elinganayo [(10mg kabili ngosuku kwabesilisa, kanye ekuseni kanye nakusihlwa; 5mg kabili ngosuku kwabesifazane, kanye ekuseni kanye nakusihlwa)]
Ukwelashwa komjikelezo weposi akudingeki ngemuva komjikelezo weCarardarine wedwa njengoba kungenayo i-hormonal. Le SARM ifakwe kahle ngeMK-2866 (Ostarine) ne-S-4 (Andarine).
Amathiphu Nokuqapha
- I-GW-501516 (Cardarine) ayinconywa ukuncelisa kanye nabesifazane abakhulelwe.
- Le nhlanganisela ayelulekwa kubantu abanokungezwani komzimba okukhona nezithako zayo ezisebenzayo nezingasebenzi.
- I-Cardarine kufanele igcinwe ekamelweni lokushisa kude nokushisa nomswakama.
- Ukusetshenziswa kweCarardarine kufanele kube njalo ngezinjongo zomthetho nezokwelapha futhi ngaphansi kokuqondiswa ngudokotela. Noma ikuphi ukusetshenziswa okukhona kwemithi kadokotela kanye nemithi ethengiswayo, amavithamini, nemikhiqizo yamakhambi kufanele kudalulwe kudokotela ngaphambi kokufuna izeluleko kudokotela.
I-GW-501516akuyona into emfushane ngomuthi omangazayo uma kuziwa ekuthatheni amazinga okukhuthazeka abe ngamazinga ahluke ngokuphelele futhi angakaze abe khona ngaphambili. Sebenzisa le nhlanganisela ngokuzibophezela ukuze uhlale eduze nokuthuthuka okukhulu emazingeni amandla, ukukhuthazela, nobukhulu bemisipha ngenkathi unomphumela omuhle ekucindezelweni kwegazi kanye nephrofayili ye-lipid.
Thenga ibanga lekhwalithi ye-premium kanye nebanga locwaningo i-GW-501516 (Cardarine) kuphela kusuka kumhlinzeki odumile wabamukeli be-androgen receptor abakhethayo abangempela nabasemthethweni abanjengo Isitolo se-SARM.