I-SR-9009 (Stenabolic)
Namuhla, ama-Selective Androgen Receptor Modulators (SARMs) anjenge I-Stenabolic yizindebe ezibalulekile emhlabeni wezithako zokwakha umzimba. Lokhu akukhona nje ukuthi balingisa imiphumela emangalisayo ye-testosterone, kodwa futhi ngoba ababangeli imiphumela emibi ye-anabolic steroids.
Kuyini iStenabolic?
I-Stenabolic (noma i-SR-9009) yasungulwa ekuqaleni nguSolwazi Thomas Burris eScripps Research Institute. Ngo-2013, a cwaningo ishicilelwe ku Ijenali Yemithi Yemvelo lokho okuphakanyisiwe i-SR-9009 isiza ukukhuluphala nokubekezela kumamodeli wezilwane.
Kuphakanyiswe yilolu cwaningo ukuthi iStenabolic inamandla ayingqayizivele shintsha iwashi lomzimba lomzimba eliyisisekelo. Leli washi linomsebenzi wokuqinisekisa ukuthi izigqi zomzimba zivumelaniswa nemini nobusuku.
Ucwaningo luphinde lwembula ukuthi amagundane entule i-Rev-erbA ayenesisindo esiphansi semisipha nokusebenza kwamathambo, kanye nokubhekana nokuvinjelwa kumandla we-cardio. I-Rev-erbA iwuhlobo lwe-receptor yenuzi elawula iwashi lomzimba, elithinta i-metabolic, endocrine, kanye nezindlela zokuzivikela ezifweni.
Noma kunjalo, lokhu ukuntuleka kweRev-erbA kwalungiswa ngemuva kokuphathwa kwe-Stenabolic. I-Rev-erbA yabo yenziwe yasebenza, futhi izihloko zabona ukukhuphuka kwamazinga emazingeni omsebenzi we-metabolic kanye ne-cardio. Uma kungagcini lapho, izikhathi zabo zokugijima namabanga abo enyuke ngamaphesenti angaphezu kwama-40.
Ngaphezu kwalokho, amagundane athuthukisa imisipha ehlotshaniswa neminyaka yokuqeqeshwa kwe-cardio - yize ilawulwa nge-Stenabolic isikhashana. Isizathu esiyisisekelo ukuthi ukusebenza kweRev-erbA kuholele kwimitochondria entsha, esiza umzimba ukuthi ulahle ezindala ezingasebenzi.
I-Stenabolic yisidakamizwa se-Rev-erbA agonist. Umzimba unesakhiwo semvelo samangqamuzana esaziwa nge-Rev-erbA esibhekele ukwenziwa kwemisebenzi ehlukahlukene, kufaka phakathi kepha kungagcini lapho:
- Ukulawula i-lipid ne-glucose metabolism;
- Ukususa amangqamuzana afayo noma afile ngesikhathi sokuvuvukala;
- Ukugcina amaseli amafutha.
Akuthathi ubuhlakani ukubona ukuthi kuzwakala kujabulisa kanjani ukuthuthukisa ukubonakaliswa kofuzo komzimba wakho. Cabanga nje ukuthi yini le SARM engayenza uma usuvele usesimweni esihle!
I-Stenabolic ivame ukubikwa njengesidakamizwa esiyisimangaliso kunoma ngubani okhathele ukukhathala ekusebenzeni kwabo. I-SR-9009 ingakusiza ukuthi ugijime ngesivinini esihle, futhi uhambe ngamaphesenti angama-75 kuphela wokushaya kwenhliziyo yakho okuhle ngesikhathi sokuzivocavoca ngokuqhathanisa namaphesenti ajwayelekile angama-90. Lokhu ngokusobala kusho ukuthi unesikhala esengeziwe sokugijima ngokushesha futhi ucindezele kanzima - nazo zonke lezi zinzuzo ngaphandle kokukhathala.
Yiziphi Izinzuzo Ze-Stenabolic Yekulahlekelwa Kwamafutha?
Ngokungangabazeki, i-SR-9009 noma i-Stenabolic ingenye yama-SARM athandwa kakhulu ezimakethe zezempilo, ukuqina komzimba nokwakha umzimba. Imvamisa, abantu basebenzisa i-Stenabolic ekulahlekelweni kwamafutha, futhi kuyasiza kakhulu kunoma ngubani ofuna ukuthuthukisa amazinga amandla. Akukhona lokhu kuphela, kusebenza ngokulinganayo ekuvuseleleni ukuthuthuka okumangazayo kwe-glucose ne-lipid metabolism emzimbeni.
I-stenabolic ingenye yezakhi ezimbalwa kakhulu ezithuthukisa umuzwa wenhlalakahle jikelele ngendlela engaphezu kweyodwa elula. Ucwaningo lukhombisile ukuthi lunganciphisa izinto ezithile emzimbeni ngamazinga alandelayo:
- Ama-plasma triglycerides: 12%;
- I-Plasma glucose: 19%;
- I-plasma insulin: 35%;
- Ingqikithi ye-cholesterol: 47%;
- Ama-fatty acids angaqinisekisiwe ePlasma: 23%.
Hhayi lokhu kuphela kepha i-SR-9009 ibuye yehlise i-cytokine IL-6 e-proinfigueatory nge-72%.
Ukusetshenziswa kwe-Stenabolic yokulahleka kwamafutha, amasonto ayi-8-12 emadodeni, kuhlotshaniswa nokwehliswa okukhulu ezingeni lokuwohloka kwe-cholesterol yesibindi okuhlobene nengozi enkulu yezinkinga zempilo njengezifo zenhliziyo nemithambo yegazi.
Ngaphezu kwalokho, ukusetshenziswa kwe-SR-9009 kuxhumene nokwehliswa kwamazinga e-triglyceride yegazi, into leyo emazingeni aphezulu ehlotshaniswa nempilo yenhliziyo ebuthakathaka.
Izinzuzo eziningi ze-SR-9009
I-Stenabolic ingelinye lama-Modulators we-Selective Androgen Receptor Modulators emhlabeni uma kukhulunywa ngokulahlekelwa amafutha anenkani esiswini nawama-visceral. Kubonisa ukusebenza kahle okukhulu uma kuziwa ekugcineni imetabolism ohlangothini oluphakeme, kuyenze ibe yinkompo ephumelela kakhulu uma kukhulunywa ngokulahlekelwa ngamafutha.
Ngaphezu kwalezi zinzuzo, iStenabolic isiza ukuguqula i-glucose ibe ngumthombo wamandla. Lokhu kusetshenziswa yimisipha njengophethiloli wokusinika amandla ekusebenzeni okukhulu. Kuyafaneleka ukuqaphela lapha ukuthi amazinga e-insulin egazi alawulwa ngokuzenzekelayo lapho i-glucose yegazi lomzimba isendaweni esezingeni eliphilile.
Lokhu kusiza ekwakheni imisipha ngokushayela ama-amino acid asuka egazini aye ezicutshini zemisipha.
Akunakuphikwa ukuthi ukulawula amazinga e-glucose kungenye yezinto ezibaluleke kakhulu ekuthuthukiseni ubuhle bomzimba. I-Stenabolic ibekiwe kabanzi futhi isetshenziswa ekwelapheni isifo sikashukela soHlobo 2.
Lokhu kungenxa yokuthi i-SR-9009 inciphisa ukubalwa kwamazinga eglucose egazi namazinga e-triglyceride, njengoba kuchaziwe ngenhla. Lapho izitolo ezinoshukela zomzimba zigcwele, zichitheka egazini. Insalela iyaguqulwa futhi igcinwe njengamafutha omzimba angafuneki. Ngokulawula amazinga eglucose egazini, umthwalo kuma-pancreas (okhiqiza i-insulin) uyehla.
Lesi sithasiselo sidlala indima ebucayi ekunciphiseni ubungozi bokukhuluphala, futhi sivimbele futhi sisize ukuphatha uhlobo lwesifo sikashukela sohlobo 2. Imithi ayikwazi ukuguqula njalo yonke imiphumela yezifo ezinjengalezi, kepha ukulahleka kwamafutha we-Stenabolic phakathi kwezinye izinzuzo kungenza impilo ibe nempilo futhi ilawuleke, nsuku zonke nasesikhathini eside. Ukugcina isisindo esinempilo kusiza ukugcina umzimba uzinzile futhi kunciphisa ubungozi bokushintshashintsha okukhulu emazingeni kashukela egazini.
I-Stenabolic nayo isetshenziselwa ukulwa nemiphumela yokuwohloka okuhlobene nobudala emandleni nasemisipha.
Akukhona nje kuphela ukuthi imisipha mikhulu ejimini nasesibukweni: kuyadingeka futhi ukumunca kahle ushukela wegazi. Ukwehliswa kwamandla kukhuphula amazinga e-insulin. Ngamafuphi, kukhona ukuxhumana okuyisisekelo phakathi kwesibalo “esiphelele” somuntu semisipha nohlobo 2 sikashukela. Kungenxa yalesi sizathu ukuthi ifomethi yezikhathi zokuqeqeshwa ukumelana ne-HIIT kanye ne-cardio inconywa kubantu abangaphezu kweminyaka yobudala engama-35.
I-Stenabolic yisidakamizwa esinamandla ngokwedlulele sokuthuthukisa amazinga okuqina nokukhuthazela, futhi lokhu kuqhubeka nokuhumushela ekuzuzeni amandla emisipha.
Abasebenzisi abaningi be-SR-9009 bakhetha ukuqeqesha kwesokudla baphakamise izinsimbi ezisindayo (amaphesenti ayi-1RM kanye) ngamasethi ancishisiwe ka-85-1, nohlu oluphansi lwe-rep olungu-3-2 ngezikhawu ezengeziwe zokuphumula zemizuzu engu-5 yokuhlanganisa phakathi kwamasethi.
Lelisu lokuzivocavoca nge-Stenabolic lisiza kakhulu ekwehliseni amazinga okukhathala, ukuthuthukisa amazinga amandla, nokwenza ngcono ukukhuthazela kokuzivocavoca.
Lesi sithasiselo sokwakha umzimba sisebenza futhi ngokweqile uma kuziwa ekwakheni imisipha eqinile. I-SR-9009 ivuselela ukubalwa kwe-mitochondria ngaphakathi kwamaseli emisipha yomzimba. Ngenxa yalokhu, abasebenzisi bangaqhuma ngokushesha ngezikhathi zokuzivocavoca ezinzima futhi bapakishe imisipha eqinile impela.
Ukusetshenziswa kwe-Stenabolic, amasonto ayi-8 kuya ku-12 (kwabesilisa), kuhlotshaniswa nomzimba wemisipha onamafutha futhi ohlanzekile.
Kwabaningi abakha umzimba kanye nama-powerlifters, ukukhathala kungenye yezingqinamba ezinkulu ngesikhathi sokuzivocavoca okukhulu. I-stenabolic yi-SARM ephelele yalokhu njengoba ibopha futhi isebenzise amaprotheni.
I-SR-9009 isebenza kumazinga amabili ahlukene: ithuthukisa ukubalwa kwawo womabili ama-mitochondria nama-macrophages. Ngokwenza lokhu, ihlanganisa yonke i-mitochondria enamaphutha kumaseli emisipha yomzimba, okuthi uma ikusiza ngempumelelo ikunike amandla ngokuzivocavoca kanzima isikhathi eside.
Ukuxhaphaza
I-Stenabolic ikuvumela ukuthi uqeqeshe isikhathi eside futhi kanzima ngamandla amakhulu. Lokhu kukusiza ukuthi uthole isisindo esiqinile semisipha futhi uhlale uphezulu emandleni, ekusebenzeni, nasemandleni.
cutting
I-stenabolic ayaziwa ngokuthi "ukuzivocavoca ebhodleleni" ize. Ingesinye sezithasiselo ezinamandla kakhulu zemijikelezo yokusika, futhi izakhiwo zokulahleka kwamafutha zikaStenabolic zigujwa kabanzi.
Ikuvumela ukuthi usebenze ejimini ngokusebenza okuthuthukisiwe nemiphumela, ukuze ukwazi ukukhipha ama-kilos athe xaxa noma ngabe umzimba usesimweni sokushoda kwekhalori. Izakhiwo zayo ezihlukile zokulahleka kwamafutha zisiza abasebenzisi bayo ukuthi balondoloze ubukhulu bemisipha futhi balahle amaphesenti amafutha omzimba ngasikhathi sinye.
Uyini isilinganiso se-SR-9009?
I-Stenabolic (SR-9009) idosiwe kangcono ku-30mg nsuku zonke kwabesilisa, ihlukaniswe ngamanani ayisithupha alinganayo we-6mg njalo emahoreni ama-5. Lokhu kungenxa yokuthi inempilo efushane ngokwedlulele, ngakho-ke imithamo ngezikhathi iyindlela ekahle yokuvuna izinzuzo ezinkulu ze-SR-2.
Ungathenga ama-SAR ku-Intanethi bese ubamba nge-RAD140, MK-677 (Ibutamoren), noma I-Ostarine (MK-2866) ukuthola imiphumela emihle.
Uyacelwa ukuthi uqaphele ukuthi imithetho yama-SARM iyahluka ngokwamazwe, ngakho-ke kufanele uhlale uqinisekisa ukuthi uhambisana nemithetho yokuhlala kwakho. Kuzo zonke izimo, kufanele uxoxe ngama-SAR kuqala nodokotela wakho ukuze uqiniseke ukuthi uthola umthamo ophephile futhi onconyiwe.
Wonke umuntu wehlukile futhi uphendula ngendlela ehlukile emithini yokwelashwa; akumele nje uzethembe wena noma imithombo engathembekile ye-Intanethi ukuthola ukuholwa okubalulekile kwezokwelapha nezomthetho.
Kubalulekile ukuthi uhlale ukhumbula ukuthi izidakamizwa, noma ngabe ama-SARM noma cha, akufanele neze zihlukunyezwe ngethemba lokuthola imiphumela esheshayo. Kubalulekile futhi ukuqaphela lapha ukuthi i-SR-9009 iyi hhayi ukuncelisa noma abesifazane abakhulelwe, noma labo abakholelwa ukuthi bangakhulelwa, noma izingane ezingaphansi kweminyaka engama-21. Ukusetshenziswa kwe-SR-9009 kufanele kube njalo ngezinhloso zokwelapha nangaphansi komthethonqubo oqinile wezokwelapha, ngaphambi nangesikhathi somthamo wakho.